The Integrity of Basal Forebrain Neurons Depends on Permanent Expression of Nkx2-1: Potential for Understanding Haploinsufficiency in Humans

نویسندگان

  • Lorenza Magno
  • T. Naumann
چکیده

s: SfN Neuroscience 2009Chicago, IL, October 17-21, 2009“Nkx2.1 transcription factor is necessary for the proper devepolment andmaintenance of the basal forebrain cholinergic neurons” Magno L., Kretz O., MonyerH., Bert B., Kimura S., Nitsch R., Naumann T. Gordon Conference “Inhibition in the CNS”Waterville, ME, July 26-31, 2009“Inactivation of Nkx2.1 in GAD-67 expressing neurons leads to deficits in movementcoordination” Magno L., Kretz O., Bert B., Monyer H., Kimura S., Nitsch R.,Naumann T.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of pre- and postnatal deletion of the transcription factor NKx2-1 on the expression of NGF, trkA, trkB and p75NTR in mice

Background Expression of the homeodomain-containing transcription factor Nkx2-1 is essential for the prenatal development of the forebrain, lungs and thyroid gland. Humans with only one functioning NKX2-1-allele, a rare genetic condition known as “NKX2-1 haploinsufficiency”, become phenotypic in early childhood. This syndrome displays a variable combination of symptoms including congenital hypo...

متن کامل

NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory

The transcription factor NKX2-1 is best known for its role in the specification of subsets of cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and intersectional focal septal deletion that NKX2-1 is selectively required in the embryonic septal neuroepithelium for the development of cholinergic septohippocampal projection neurons and large subsets of basal fo...

متن کامل

Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons

The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional identity and, with LHX6, is necessary to specify pallidal projection neurons and...

متن کامل

Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections.

We have investigated the mechanisms that control the guidance of corticofugal projections as they extend along different subdivisions of the forebrain. To this aim, we analyzed the development of cortical projections in mice that lack Nkx2-1, a homeobox gene whose expression is restricted to two domains within the forebrain: the basal telencephalon and the hypothalamus. Molecular respecificatio...

متن کامل

A study on striatal local electrical potential changes in an animal model of Parkinson's disease

Parkinson’s disease (PD) is a neurodegenerative disorder that does not develop spontaneously in some animal species. PD can be induced experimentally in some laboratory animals including mouse, rat and horse. Globus pallidus (GP) and substantia nigra pars compacta (SNc) are damaged in patients with PD. The hallmark of PD is a progressive impaired control of movement, an alteration of autonomic ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010